Laboratory directed evolution is used to engineer desired properties in proteins such as binding specificity, binding affinity, stability, catalytic activity, and expression. The input - a high-quality variant library - is critical to achieving successful results.

Revolve technology allows construction of scanning and combinatorial libraries with minimal wildtype and off-target mutations, high mutational coverage, and low bias. Revolve gives you the ability to comprehensively and efficiently explore vast sequence space that was previously off-limits and attain the results you need.

Enzymes are proteins often used for bioprocessing in bio-based chemical production, agribusiness, biofuels, and pharmaceutical manufacture. Improvements in enzyme performance can translate to billion-dollar returns in efficiency, cost-reduction, and profitability. Revolve combinatorial libraries are ideally suited for optimizing the catalytic site for achieving the desired performance characteristics.

Recombinant proteins such as antibodies and their derivatives are used to target specific disease markers for diagnostic, therapeutic, and research applications. These molecules must be engineered for maximal target specificity, affinity, and stability to achieve the desired results.

Revolve’s combinatorial libraries are ideally suited for phage, yeast, and ribosome display-based selections and scanning libraries for affinity maturation.